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Most anal cancers (80) are diagnosed in people who are over age 60. However, after age 50, anal cancer is slightly more common in women. Anal cancer is cancer that arises in the anus, the end of the intestinal tract where stool (feces) exits the body. The cancer can begin either in the lining of the anus or in the skin surrounding the anus. Anal cancer is different from colon or rectal cancer, which arises in the other parts of the large intestine. Risk factors for developing anal cancer include infection with certain types of. At first, most people assume the bleeding is caused by hemorrhoids (painful, swollen veins in the anus and rectum that may bleed). The symptoms of anal cancer are often similar to more common and less serious conditions affecting the anus, such as piles (haemorrhoids) and small tears or sores called anal fissures. Early detection of anal cancer is common because these tumors develop in a part of the digestive tract that doctors are able to see and reach. Symptoms of early-stage anal cancer often prompt patients to visit their doctor, though not everyone experiences symptoms. More than half of patients with anal cancer experience rectal bleeding, which is often the first indication of the disease.